Handling the papaya, then touching the face may cause the eyes to itch and water. 4. Unpleasant medical symptoms are associated with a pineapple allergy. The symptoms of an allergic reaction to papaya are similar to those of other food allergies. And remember, if you have a latex allergy, an allergic reaction to proteins contained in natural rubber latex, you might also be allergic to papaya. Papaya latex can cause a severe allergic reaction in certain people. Some believe papayas may also cause dizziness, headaches, and difficulty in swallowing in certain individuals. 5. The skin of the payapa may cause itching or rash on the hands. Latex is usually obtained by cutting into unripe papaya fruits. But ripe papaya fruits contain some latex too. Some people may show symptoms of what is known as oral allergy syndrome. These allergies are a part of oral allergy syndrome, a condition common with certain fruits, including papayas. It can only be treated by keeping the symptoms under control. 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