Should I worry about a sudden swollen tongue? But later this year, a "ground-breaking" large-scale clinical trial will offer NHS patients a new form of medicine, gene silencing, in an injection called inclisiran. Don't go overboard, though. And other questions, 'I didnât know other LGBT Muslims existed' Video'I didnât know other LGBT Muslims existed', Covid and schools: 'Kids know things aren't right'. In addition, it's a good reminder to people with worrisomely high LDL values who have not had a heart attack to pay close attention to their cholesterol, Dr. Cannon says. The drug is offered in two FDA-approved formulations to lower LDL cholesterol levels in patients who are intolerant of statins. What does Ethiopia's Tigray crisis mean for the region? They're intended for people whose cholesterol levels remain stubbornly high, despite making lifestyle changes (such as diet and exercise) and taking the maximum dose of a high-potency statin and other cholesterol-lowering drugs. The Australian city recorded a minimum overnight temperature of 25.4C. The .css-yidnqd-InlineLink:link{color:#3F3F42;}.css-yidnqd-InlineLink:visited{color:#696969;}.css-yidnqd-InlineLink:link,.css-yidnqd-InlineLink:visited{font-weight:bolder;border-bottom:1px solid #BABABA;-webkit-text-decoration:none;text-decoration:none;}.css-yidnqd-InlineLink:link:hover,.css-yidnqd-InlineLink:visited:hover,.css-yidnqd-InlineLink:link:focus,.css-yidnqd-InlineLink:visited:focus{border-bottom-color:currentcolor;border-bottom-width:2px;color:#B80000;}@supports (text-underline-offset:0.25em){.css-yidnqd-InlineLink:link,.css-yidnqd-InlineLink:visited{border-bottom:none;-webkit-text-decoration:underline #BABABA;text-decoration:underline #BABABA;-webkit-text-decoration-thickness:1px;text-decoration-thickness:1px;-webkit-text-decoration-skip-ink:none;text-decoration-skip-ink:none;text-underline-offset:0.25em;}.css-yidnqd-InlineLink:link:hover,.css-yidnqd-InlineLink:visited:hover,.css-yidnqd-InlineLink:link:focus,.css-yidnqd-InlineLink:visited:focus{-webkit-text-decoration-color:currentcolor;text-decoration-color:currentcolor;-webkit-text-decoration-thickness:2px;text-decoration-thickness:2px;color:#B80000;}}first gene-silencing medicine was approved for NHS use last year for a relatively rare disease, hereditary trans thyretin-mediated amyloidosis. .css-8h1dth-Link{font-family:ReithSans,Helvetica,Arial,freesans,sans-serif;font-weight:700;-webkit-text-decoration:none;text-decoration:none;color:#FFFFFF;}.css-8h1dth-Link:hover,.css-8h1dth-Link:focus{-webkit-text-decoration:underline;text-decoration:underline;}Read about our approach to external linking. However, some patients have such high cholesterol that it is still at dangerous levels even with statins. Both are given by a self-administered injection once or twice a month. "If someone has had trouble with statins in the past, we have to provide the dose, the dates, and the person's response to at least two and sometimes three different statins," Dr. Cannon explains. Bempedoic acid is a new type of cholesterol-fighting drug that doesn't come with muscle-related side effects common with statins and could be an alternative. And studies have shown they do not work well enough in roughly half of patients. Disclaimer: Can adopting a healthier diet help fight prostate cancer? As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Can a smart watch diagnose a heart attack? Cholesterol-lowering pill 'new option for statin users', What does Ethiopia's Tigray crisis mean for the region? 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