You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. A natural alternative for lowering LDL … If you are allergic to Zetia (ezetimibe); any part of Zetia (ezetimibe); or any other drugs, foods, or substances. The study is created by eHealthMe based on reports of 13 people who take Zetia and Alcohol from the FDA, and is updated regularly. Ezetimibe / simvastatin systemic 10 mg / 10 mg (TEVA 7584). Using ezetimibe together with simvastatin can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. Other drugs that have the same active ingredients (e.g. Interactions; More; Uses of Zetia: It is used to lower cholesterol. (2008): 463-74, Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors." Most of it side effects are GI --indigestion and changes in bowel habits. Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Zetia, atorvastatin, simvastatin, rosuvastatin, Lipitor, Crestor, evolocumab. It is often used in high blood cholesterol. Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. Available for Android and iOS devices. * Approximation only. Ezetimibe interaction with Food, Herbs and Alcohol - It is important to know how to take the medication to avoid the drug-food interaction. Alcohol has active ingredients of alcohol. Zetia and Alcohol drug interactions by gender *: Zetia and Alcohol drug interactions by age *: Personalize this study to your gender and age (0-99+), and then find any serious effects. Different individuals may respond to medication in different ways. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. They can include severe muscle pain and kidney damage, among other significant adverse reactions. Drug Information on Zetia (ezetimibe) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Select one or more newsletters to continue. Merck & Co, Inc, West Point, PA. Kantola T, Kivisto KT, Neuvonen PJ "Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid." [See also DRUG INTERACTIONS] ZETIA had no significant effect on a series of probe drugs (caffeine, dextromethorphan, tolbutamide, and IV midazolam) known to be metabolized by cytochrome P450 (1A2, 2D6, 2C8/9 and 3A4) in a “cocktail” study of twelve healthy adult males. Clin Pharmacol Ther 63 eHealthMe is studying from 43,144 Zetia users now. Talk to your doctor or pharmacist if you have any questions or concerns. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. "Product Information. Moderately clinically significant. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should limit the use of alcohol while being treated with these medications. Administration of a single 20 mg dose of simvastatin with 8 ounces of single-strength grapefruit juice increased the AUC of simvastatin and simvastatin acid by 1.9-fold and 1.3-fold, respectively. It is based on ezetimibe and alcohol (the active ingredients of Zetia and Alcohol, respectively), and Zetia and Alcohol (the brand names). Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death. If you have a history of heavy alcohol use and are taking Zetia … The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Common interactions include amnesia among females and chest pain among males. © 2020 eHealthMe.com. MANAGEMENT: Patients receiving therapy with lovastatin, simvastatin, or red yeast rice (which contains lovastatin) should be advised to avoid the consumption of grapefruit and grapefruit juice. Most of it side effects are GI --indigestion and changes in … eHealthMe makes it possible for everyone to run their own clinical trial. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. (1998): 397-402, Bailey DG, Malcolm J, Arnold O, Spence JD "Grapefruit juice-drug interactions." Br J Clin Pharmacol 46 Zetia is used to treat high cholesterol. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness while taking these medications, especially if these symptoms are accompanied by fever or dark colored urine. Zetia is sometimes given with other cholesterol-lowering medications. Do not stop using any medications without first talking to your doctor. There are 3 alcohol/food/lifestyle interactions with ezetimibe / simvastatin which include: Moderate simvastatin ↔ Alcohol (Ethanol) Moderate Drug Interaction. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The study is created by eHealthMe based on reports of 13 people who take Zetia and Alcohol from the FDA, and is updated regularly. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Interactions; More; What is Zetia? (1991): 706, Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." Also, patients should either refrain from the use of oat bran and pectin or, if concurrent use cannot be avoided, to separate the administration times by at least 2 to 4 hours. Zocor (simvastatin)." Lancet 338 ADJUST DOSING INTERVAL: Fibres such as oat bran and pectin may diminish the pharmacologic effects of HMG-CoA reductase inhibitors by interfering with their absorption from the gastrointestinal tract. Consumer information for this interaction is not currently available. What do I need to tell my doctor BEFORE I take Zetia? All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Important information. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. In some cases, rhabdomyolysis can cause kidney damage and even death. (1998): 477-83. Most likely your drugs were not approved in clinical trials based on patients like you. JAMA 289 Atorvastatin may cause liver problems and using it with substantial quantities of ethanol may increase that risk. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. There are 265 drug interactions with ezetimibe / simvastatin. By design, clinical trials use only a small and selected set of people, and are conducted in a highly controlled environment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You should limit the use of alcohol while being treated with these medications. Avoid combinations; the risk of the interaction outweighs the benefit. Common interactions include amnesia among females and chest pain among males.
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