Patients with T2DM and hypercholesterolemia with detectable sd LDL-C after receiving 10 mg/day atorvastatin for ≥24 weeks were randomly assigned to receive rosuvastatin (5 mg/day; switched treatment) or atorvastatin (10 mg/day; continued treatment) for 12 weeks. NIH Cao X, Ejzykowicz F, Ramey DR, Sajjan S, Ambegaonkar BM, Mavros P, Tunceli K. Clin Ther. The majority of patients (55.6%) were switched to atorvastatin, followed by simvastatin (24.9%), simvastatin/ezetimibe combination (10.0%) and … The final study population included 10,368 patients. This open-label, randomized, parallel-group comparative study compared the efficacy of rosuvastatin (5 mg/day) and atorvastatin (10 mg/day) for reduction of small dense low-density lipoprotein cholesterol (sd LDL-C) levels in Japanese patients with type 2 diabetes mellitus (T2DM). Switching from atorvastatin to rosuvastatin lowers small, dense low-density lipoprotein cholesterol levels in Japanese hypercholesterolemic patients with type 2 diabetes mellitus. During the observation period, 2452 (23.6%) patients were switched from rosuvastatin to another LLT. 2019 Nov 13;15:1325-1332. doi: 10.2147/TCRM.S216606. switching from rosuvastatin to atorvastatin may occur and could persist until the patent on branded rosuvastatin expires. Multiple regression analysis among all subjects revealed that independent factors contributing to the reduction in sd LDL-C levels were a change in LDL-C (p = 0.003) and triglyceride (TG) levels (p = 0.006), treatment group (the switched group = 1, the continued group = 0; standard coefficient = −1.2, p = 0.034) and baseline glycated hemoglobin A1c (HbA1c) (p = 0.045), respectively. Small dense LDL-cholesterol (sd LDL-C) levels without high LDL-C levels are involved in the development of arteriosclerosis due to lipid abnormalities in patients with type 2 diabetes mellitus. It is important to understand the impact that such therapy may have on patients' cardiovascular (CV) health. Objective: Comparison of low-density lipoprotein cholesterol reduction after switching patients on other statins to rosuvastatin or simvastatin in a real-world clinical practice setting. Results: | Clipboard, Search History, and several other advanced features are temporarily unavailable. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This study examined changes in LDL-C levels following a switch from 40/80 mg of atorvastatin (ATV) to 20/40 mg of rosuvastatin (RSV). When starting treatment with rosuvastatin or switching a patient from another statin to rosuvastatin then (1,2): all patients (including those who are switching form another statin) must start on the initial dose of 5 mg (or 10mg) of rosuvastatin once daily and should only be titrated to a higher dose after a 4 week trial . Initial statin therapy may not always adequately reduce elevated low-density lipoprotein cholesterol (LDL-C) levels. the simple act of switching all patients from atorvastatin 10 or 20mg to simvastatin 40mg would save the NHS £2bn. OBJECTIVES: This simulated study estimates the impact of switching patients Atorvastatin NON--PREFERRED Fluvastatin NON-PREFERRED Lovastatin NON-PREFERRED Pravastatin NON-PREFERRED Rosuvastatin 10 mg 40 mg 20 mg 20 mg 20 mg 10 mg 80 mg 40 or 80 mg 40 mg 40 mg 20 mg 80 mg 80 mg 5 or 10 mg 80 mg 40 mg 80 mg 20 … In addition, a recent meta-analysis of randomized trials demonstrated that rosuvastatin is more effective at reducing sd LDL levels than atorvastatin. Get the latest public health information from CDC: https://www.coronavirus.gov. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. By continuing you agree to the use of cookies. This study examined changes in LDL-C levels following a switch from 40/80 mg of atorvastatin (ATV) to 20/40 mg of rosuvastatin (RSV). Keywords: 2015 Apr 1;37(4):804-15. doi: 10.1016/j.clinthera.2014.12.019. Am J Manag Care. Please enable it to take advantage of the complete set of features! 10, pp. | Baum SJ, Wade RL, Xiang P, Arellano J, Cerezo Olmos C, Nunna S, Chen CC, Carter CM, Desai NR. Harley CR, Gandhi SK, Anoka N, Bullano MF, McKenney JM. This study examined changes in LDL-C levels following a switch from 40/80 mg of atorvastatin (ATV) to 20/40 mg of rosuvastatin (RSV).This retrospective cohort study used data from the MarketScan administrative claims databases linked to laboratory values. LDL cholesterol levels after switch from atorvastatin to rosuvastatin. Current Medical Research and Opinion: Vol. A previous study reported that the maximal dose of rosuvastatin (40 mg) is significantly more effective than the maximal dose of atorvastatin (80 mg) in lowering sd LDL-C. Lipitor and Crestor are also used to reduce the risk of heart attacks, stroke, and arterial revascularization procedures in patients with multiple risk factors for heart disease. Ther Clin Risk Manag. Although alternative therapies are available, switching to another statin may be beneficial, especially for those at highest risk of cardiovascular disease and events. However, the former group exhibited a statistically significant reduction from baseline of sd LDL-C levels, sd LDL-C/total LDL-C ratio compared with the latter group (−3.8 mg/dL vs. −1.4 mg/dL, p = 0.014; −2.3% vs. −0.6%, p = 0.004, respectively). They also claim there is no good evidence to continue Atorvastatin 10 or 20mg in inpatients and they should all be switched to generic simvastatin, pravastatin or another generic statin (1). There were no significant percent changes from baseline for LDL-C levels between the switched (n = 55) and the continued treatment group (n = 56). Epub 2018 Aug 20. Get the latest research from NIH: https://www.nih.gov/coronavirus. https://doi.org/10.1016/j.diabres.2015.10.013. 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